Have you tried doing a new, portable install, importing your tracks one by one, adding the relevant plug one by one? Sometimes it takes that level of fault-finding to narrow down exactly WHERE the problem is happening. I still have Amplitube on my studio machine but no longer use it because it IS pretty flaky for me. And FWIW I have never managed to gt SSD4 working reliably on either of my machines, even with Slate support phoning me from USA and trying to get me up and running via teamviewer. They gave up in the end, as did I. And one other thing to get out of the way. Have you already tried downloading and installing another DAW to see if it behaves the same way with these plugins? Plenty of freebie demo versions out there. Sorry I cant offer any more immediate suggestions.